Herpes Treatment Herpes is a very common skin disease. It's caused by a virus and can affect your mouth (oral) and/or the area around the penis or vagina (genital), upper thighs or buttocks. Most of the time, it is hard to notice herpes, so most people don't know they have it. Cold sores and fever blisters are an example of herpes in your mouth.Herpes simplex is most easily transmitted by direct contact with a lesion or the body fluid of an infected individual. Transmission may also occur through skin-to-skin contact during periods of asymptomatic shedding.The most common mode of transmission is through vaginal, anal or oral sex. When somebody becomes infected with HSV, it will generally remain dormant.
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